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Alzheimer's Disease

Now Viagra for Alzheimer’s too!

Used in combination with other drugs Viagra may help treat cancer and Alzheimer’s disease as well beyond, of course, erectile dysfunction.

A new study has shown that drugs like Viagra or Cialis and one of its derivatives called Celebrex can stall the activity of a chaperone protein and thereby potentially help treat tumour and Alzheimer’s disease.

The authors Laurence Booth, Jane Roberts, and Paul Dent of the bVirginia Commonwealth University in Richmond claim that OSU-03012, an experimental compound derived from Celebrex, interacts with Viagra or Cialis and lowers the level of chaperone proteins. By reducing the levels of HSPA5 and Dna K it is possible to interfere with virus replication, promote bacterial cell death and even make drug-resistant “superbugs” susceptible to existing antibiotics.

Carol Shoshkes Reiss, PhD, Editor-in-Chief, of DNA and Cell Biology and Professor, Departments of Biology and Neural Science, New York University, NY, said that the study may spawn new applications of these relatively new medicines and if the results obtained in experiments become translatable to human disease, they could be paradigm-shifting.

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